Januvia (sitagliptin) — Uses, Dosage, Side Effects & Safety

Drug class: Dipeptidyl peptidase-4 (DPP-4) inhibitor; oral hypoglycemic agent

Overview

Januvia is a prescription medicine used to help control blood sugar levels in adults with type 2 diabetes mellitus. It is not used to treat type 1 diabetes or diabetic ketoacidosis. Januvia works by increasing the levels of natural substances called incretins, which help to control blood sugar by increasing insulin release, especially after meals, and decreasing the amount of sugar made by the liver. Januvia is usually taken once daily, with or without food. It may be used alone or in combination with other diabetes medications such as metformin or sulfonylureas. Patients should continue to follow their doctor's advice about diet, exercise, and regular blood sugar monitoring while taking Januvia. Key points: Januvia does not typically cause weight gain or low blood sugar (hypoglycemia) when used alone. However, it may cause low blood sugar if combined with other diabetes medicines. Always inform your healthcare provider about all medications you are taking.

Therapeutic uses

• Type 2 Diabetes Mellitus (monotherapy)
• Type 2 Diabetes Mellitus (in combination with metformin)
• Type 2 Diabetes Mellitus (in combination with a sulfonylurea)
• Type 2 Diabetes Mellitus (in combination with a thiazolidinedione)
• Type 2 Diabetes Mellitus (in combination with insulin)

Common side effects

• Hypoglycemia
• Upper respiratory tract infection
• Nasopharyngitis
• Headache
• Pancreatitis
• Severe allergic reactions
• Joint pain

Frequently Asked Questions about Januvia

What is Januvia used for?

Januvia is used to help control blood sugar levels in adults with type 2 diabetes mellitus. It is not used for type 1 diabetes or diabetic ketoacidosis.

How does Januvia work?

Januvia works by increasing the levels of incretin hormones, which help the body release more insulin after meals and decrease the amount of sugar produced by the liver.

Can Januvia cause low blood sugar?

Januvia alone rarely causes low blood sugar (hypoglycemia), but the risk increases if it is used with other diabetes medications such as insulin or sulfonylureas.

What should I do if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double up on doses.

Are there any foods or drinks I should avoid while taking Januvia?

Avoid excessive alcohol, as it can affect blood sugar control and increase the risk of side effects. Maintain a healthy diet as advised by your doctor.

Can I take Januvia if I have kidney problems?

Januvia can be used in patients with kidney impairment, but the dose may need to be adjusted. Your doctor will determine the appropriate dose for you.

Is Januvia safe during pregnancy or breastfeeding?

The safety of Januvia during pregnancy or breastfeeding is not well established. Discuss with your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.