Kisqali (Ribociclib) (Ribociclib) — Uses, Dosage, Side Effects & Safety

Drug class: CDK4/6 inhibitor (Cyclin-Dependent Kinase 4 and 6 inhibitor)

Overview

Kisqali (Ribociclib) is a prescription medicine used to treat certain types of breast cancer. It is typically prescribed for hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced or metastatic breast cancer, often in combination with other hormonal therapies such as aromatase inhibitors or fulvestrant. Ribociclib works by blocking proteins called cyclin-dependent kinases 4 and 6 (CDK4/6), which are involved in cell division. By inhibiting these proteins, Kisqali helps slow down or stop the growth of cancer cells. Key points for patients: Kisqali is taken by mouth, usually once daily for 21 days followed by 7 days off in a 28-day cycle. Regular blood tests are needed to monitor for side effects. It is important to take Kisqali exactly as prescribed and to report any unusual symptoms to your healthcare provider.

Therapeutic uses

• Hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced or metastatic breast cancer in combination with an aromatase inhibitor as initial endocrine-based therapy
• Hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced or metastatic breast cancer in combination with fulvestrant as initial endocrine-based therapy or after disease progression on prior endocrine therapy
• Hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced or metastatic breast cancer in pre/perimenopausal women in combination with an aromatase inhibitor and a luteinizing hormone-releasing hormone (LHRH) agonist

Common side effects

• Neutropenia
• Leukopenia
• Nausea
• Fatigue
• Diarrhea
• Hair loss
• QT prolongation
• Hepatotoxicity

Frequently Asked Questions about Kisqali (Ribociclib)

What is Kisqali (Ribociclib) used for?

Kisqali is used to treat hormone receptor-positive, HER2-negative advanced or metastatic breast cancer, usually in combination with other hormonal therapies.

How does Kisqali work?

Kisqali blocks CDK4 and CDK6 proteins, which are involved in cell division, helping to slow or stop the growth of cancer cells.

What are the most common side effects?

Common side effects include nausea, fatigue, diarrhea, hair thinning, and low white blood cell counts.

Can I take Kisqali if I am pregnant or breastfeeding?

No, Kisqali is not recommended during pregnancy or breastfeeding due to potential harm to the baby.

What should I do if I miss a dose?

Skip the missed dose and take your next dose at the usual time. Do not double up doses.

Are there foods or drugs I should avoid while taking Kisqali?

Yes, avoid grapefruit products and medications that can affect liver enzymes or prolong the QT interval.

How often will I need blood tests while on Kisqali?

You will need regular blood tests to monitor your blood counts, liver function, and heart rhythm during treatment.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.