Letrozole (letrozole) — Uses, Dosage, Side Effects & Safety

Drug class: Aromatase inhibitor (Antineoplastic agent)

Overview

Letrozole is a prescription medication used primarily to treat hormone receptor-positive breast cancer in postmenopausal women. It works by lowering estrogen levels in the body, which helps slow or stop the growth of certain types of breast tumors that need estrogen to grow. Letrozole belongs to a group of medicines called aromatase inhibitors. By blocking the aromatase enzyme, it reduces the amount of estrogen produced, making it effective in treating breast cancer and sometimes used off-label for fertility issues. Key points: Letrozole is not suitable for use in premenopausal women unless specifically directed by a doctor. It should be taken exactly as prescribed, and regular follow-up with your healthcare provider is important to monitor for side effects and effectiveness.

Frequently Asked Questions about Letrozole

What is letrozole used for?

Letrozole is mainly used to treat hormone receptor-positive breast cancer in postmenopausal women. It may also be used off-label for fertility treatment in women with ovulatory disorders.

How long do I need to take letrozole?

The duration of letrozole treatment varies, but it is often prescribed for 5 years or longer for breast cancer. Your doctor will determine the best length of therapy for your situation.

Can letrozole cause bone loss?

Yes, letrozole can decrease bone mineral density, increasing the risk of osteoporosis and fractures. Your doctor may monitor your bone health and recommend supplements or medications if needed.

Is letrozole safe during pregnancy?

No, letrozole can harm an unborn baby and should not be used during pregnancy. Effective contraception is recommended during treatment.

What should I do if I experience severe side effects?

Contact your healthcare provider immediately if you experience serious side effects such as chest pain, severe allergic reactions, or signs of blood clots.

Can I take letrozole with other cancer medications?

Letrozole may be used in combination with other cancer therapies, but some drugs (like tamoxifen) may reduce its effectiveness. Always consult your doctor before combining treatments.

Are there dietary restrictions with letrozole?

There are no specific dietary restrictions, but maintaining a healthy diet and adequate calcium and vitamin D intake is important for bone health.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.