Ospemifene — Uses, Dosage, Side Effects & Safety

Drug class: Selective Estrogen Receptor Modulator (SERM)

Overview

Ospemifene is a prescription medication used to treat moderate to severe dyspareunia (painful sexual intercourse) caused by vulvar and vaginal atrophy due to menopause. It works by acting like estrogen in certain tissues of the body, helping to improve the thickness and moisture of vaginal tissues. Ospemifene is not a hormone, but a selective estrogen receptor modulator (SERM). This means it can mimic some of the effects of estrogen in the vagina while blocking estrogen effects in other tissues. It is taken by mouth, usually once daily, and is intended for use in postmenopausal women who experience discomfort during intercourse. Key points: Ospemifene is not for use in women with a history of certain cancers or blood clots. It should not be used to prevent heart disease or dementia. Patients should be aware of potential side effects and discuss any concerns with their healthcare provider.

Therapeutic uses

• Dyspareunia due to vulvar and vaginal atrophy associated with menopause
• Moderate to severe symptoms of vulvar and vaginal atrophy associated with menopause

Common side effects

• Hot flashes
• Vaginal discharge
• Muscle spasms
• Increased risk of blood clots
• Stroke
• Endometrial cancer
• Uterine thickening

Frequently Asked Questions about Ospemifene

What is ospemifene used for?

Ospemifene is used to treat moderate to severe dyspareunia (painful intercourse) caused by vulvar and vaginal atrophy in postmenopausal women.

How does ospemifene work?

Ospemifene acts as a selective estrogen receptor modulator (SERM), mimicking estrogen's effects in vaginal tissues to improve thickness and moisture.

Who should not take ospemifene?

Women with a history of blood clots, stroke, heart attack, or estrogen-dependent cancers should not take ospemifene.

What are the most common side effects?

The most common side effects are hot flashes, vaginal discharge, muscle spasms, and increased sweating.

Can ospemifene be used with other estrogen therapies?

Ospemifene should not be used with other estrogen-containing medications unless specifically directed by your doctor.

Is ospemifene safe during pregnancy?

Ospemifene is not indicated for use in pregnant women and should not be used during pregnancy.

How long does it take for ospemifene to work?

Some women may notice improvement in symptoms within a few weeks, but full benefits may take up to 12 weeks.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.