Panitumumab (panitumumab) — Uses, Dosage, Side Effects & Safety

Drug class: Monoclonal Antibody; Epidermal Growth Factor Receptor (EGFR) Inhibitor; Antineoplastic Agent

Overview

Panitumumab is a targeted cancer therapy used to treat certain types of metastatic colorectal cancer. It works by blocking a protein called the epidermal growth factor receptor (EGFR), which is involved in the growth and spread of cancer cells. By inhibiting EGFR, panitumumab can slow or stop the progression of tumors that rely on this pathway. This medication is typically used in adults whose tumors do not have mutations in the RAS gene (wild-type RAS). It is given as an intravenous infusion, usually in combination with other chemotherapy drugs or as a single agent if other treatments have not worked. Patients should be aware that panitumumab can cause skin reactions, electrolyte imbalances, and other side effects, so regular monitoring and communication with the healthcare team are important.

Therapeutic uses

• Metastatic colorectal cancer (mCRC) with wild-type RAS
• First-line treatment of mCRC in combination with FOLFOX
• Second-line treatment of mCRC in combination with FOLFIRI
• Monotherapy for mCRC after failure of fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy

Common side effects

• Acneiform rash
• Diarrhea
• Hypomagnesemia
• Fatigue
• Nausea
• Abdominal pain
• Pulmonary fibrosis
• Infusion-related reactions

Frequently Asked Questions about Panitumumab

What is panitumumab used for?

Panitumumab is used to treat metastatic colorectal cancer in adults whose tumors do not have RAS gene mutations. It is often used when other treatments have not worked or in combination with chemotherapy.

How does panitumumab work?

Panitumumab is a monoclonal antibody that blocks the epidermal growth factor receptor (EGFR) on cancer cells, slowing their growth and spread.

What are the most common side effects?

The most common side effects are skin rash, itching, dry skin, nail changes, diarrhea, and mild infusion reactions.

Can panitumumab be used in children?

Panitumumab is not routinely recommended for use in children, as safety and effectiveness have not been established in pediatric patients.

What should I do if I miss a dose?

Contact your healthcare provider as soon as possible to reschedule your infusion. Do not try to make up a missed dose on your own.

Are there any foods or activities I should avoid?

Avoid excessive sun exposure and use sunscreen, as panitumumab can make your skin more sensitive to sunlight. Also, avoid live vaccines during treatment.

Is genetic testing required before starting panitumumab?

Yes, genetic testing for RAS mutations is required. Panitumumab is only effective in patients with wild-type (non-mutated) RAS tumors.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.