Upadacitinib — Uses, Dosage, Side Effects & Safety

Drug class: Janus kinase (JAK) inhibitor

Overview

Upadacitinib is a prescription medication used to treat several autoimmune and inflammatory conditions, including moderate to severe rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, atopic dermatitis (eczema), and ulcerative colitis in adults and certain adolescents. It works by blocking specific enzymes (Janus kinases or JAKs) involved in the immune system's inflammatory response, helping to reduce pain, swelling, and other symptoms. Patients taking upadacitinib should be aware that it can lower the body's ability to fight infections and may increase the risk of serious infections, blood clots, and certain cancers. Regular monitoring and communication with your healthcare provider are important while on this medication. Key points: Take upadacitinib exactly as prescribed, do not stop suddenly without consulting your doctor, and report any signs of infection or unusual symptoms promptly.

Therapeutic uses

• Rheumatoid arthritis
• Psoriatic arthritis
• Ankylosing spondylitis
• Ulcerative colitis
• Atopic dermatitis

Common side effects

• Upper respiratory tract infections
• Nausea
• Headache
• Acne
• Increased risk of serious infections
• Increased risk of blood clots
• Increased risk of malignancy

Frequently Asked Questions about Upadacitinib

What conditions does upadacitinib treat?

Upadacitinib is used to treat moderate to severe rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, atopic dermatitis, and ulcerative colitis in adults and certain adolescents.

How long does it take for upadacitinib to work?

Some patients may notice improvement in symptoms within a few weeks, but full effects may take several months depending on the condition being treated.

Can I take upadacitinib if I have a history of infections?

Upadacitinib can increase the risk of infections. If you have a history of chronic or recurrent infections, discuss this with your doctor before starting the medication.

Is upadacitinib safe during pregnancy or breastfeeding?

Upadacitinib is not recommended during pregnancy or breastfeeding unless clearly needed. Discuss risks and benefits with your healthcare provider.

Can I receive vaccines while on upadacitinib?

You should avoid live vaccines while taking upadacitinib. Inactivated vaccines may be given, but consult your doctor first.

What should I do if I develop signs of infection?

Contact your healthcare provider immediately if you develop fever, chills, cough, or other signs of infection while taking upadacitinib.

Are there any foods or drinks I should avoid?

Avoid grapefruit and grapefruit juice, as they can increase upadacitinib levels in your blood.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.