Xgeva (denosumab) — Uses, Dosage, Side Effects & Safety

Drug class: Monoclonal antibody; RANK ligand (RANKL) inhibitor; Bone-modifying agent

Overview

Xgeva is a prescription medicine used to prevent serious bone problems (such as fractures, spinal cord compression, or the need for radiation or surgery to the bone) in people with bone metastases from solid tumors, such as breast, prostate, or lung cancer. It is also used to treat giant cell tumor of bone that cannot be surgically removed or when surgery is not the best option. Xgeva works by blocking a protein called RANK ligand (RANKL), which is involved in the breakdown of bone. By inhibiting RANKL, Xgeva helps strengthen bones and reduce the risk of complications related to bone metastases. Key points: Xgeva is given as an injection under the skin, usually every 4 weeks. It is important to take calcium and vitamin D supplements as directed by your doctor to help prevent low blood calcium levels. Regular monitoring and dental check-ups are recommended during treatment.

Therapeutic uses

• Prevention of skeletal-related events in patients with multiple myeloma and in patients with bone metastases from solid tumors
• Treatment of giant cell tumor of bone in adults and adolescents with mature skeletons
• Treatment of hypercalcemia of malignancy refractory to bisphosphonate therapy

Common side effects

• Hypocalcemia
• Osteonecrosis of the jaw (ONJ)
• Atypical femoral fracture
• Serious infections
• Back pain
• Musculoskeletal pain
• Dermatitis

Frequently Asked Questions about Xgeva

What is Xgeva used for?

Xgeva is used to prevent bone complications in people with bone metastases from solid tumors and to treat certain cases of giant cell tumor of bone.

How is Xgeva administered?

Xgeva is given as a subcutaneous injection (under the skin) by a healthcare professional, usually every 4 weeks.

What should I do if I miss a dose?

Contact your healthcare provider as soon as possible to reschedule your missed dose. Do not take extra doses on your own.

Can I take Xgeva if I have kidney problems?

People with kidney problems may be at higher risk for low calcium levels while taking Xgeva. Your doctor will monitor your calcium closely and may adjust your supplements.

What are the most serious side effects of Xgeva?

Serious side effects include low blood calcium, osteonecrosis of the jaw, atypical femur fractures, and severe infections. Seek medical attention if you experience symptoms such as jaw pain, muscle cramps, or signs of infection.

Can I have dental work while on Xgeva?

Inform your dentist that you are receiving Xgeva before any dental procedures. Preventive dental care is recommended before starting treatment.

Is Xgeva safe during pregnancy or breastfeeding?

Xgeva is not recommended during pregnancy or breastfeeding due to potential risks to the baby. Discuss with your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.