Zilretta (Triamcinolone acetonide ER) (Triamcinolone acetonide extended-release) — Uses, Dosage, Side Effects & Safety

Drug class: Musculoskeletal & Connective Tissue

Overview

Zilretta (Triamcinolone acetonide ER) is a long-acting corticosteroid medication used to relieve pain associated with osteoarthritis of the knee. It is administered as an injection directly into the knee joint, where it works by reducing inflammation and swelling, leading to decreased pain and improved joint function. Unlike traditional corticosteroid injections, Zilretta uses an extended-release formulation, allowing the medication to be slowly released over several weeks. This provides longer-lasting pain relief compared to immediate-release corticosteroid injections. Key points for patients: Zilretta is not a cure for osteoarthritis but can help manage symptoms. It should not be used in other joints or for systemic conditions. Always have the injection administered by a healthcare professional.

Therapeutic uses

• Osteoarthritis pain of the knee

Common side effects

• Arthralgia
• Headache
• Nausea
• Injection site pain
• Hypersensitivity reactions
• Osteonecrosis
• Cushing's syndrome

Frequently Asked Questions about Zilretta (Triamcinolone acetonide ER)

How long does pain relief from Zilretta last?

Pain relief typically begins within a few days and can last up to 12 weeks or longer for many patients.

Can Zilretta be used in both knees at the same time?

Zilretta is approved for use in one knee at a time. If both knees require treatment, your doctor will determine the appropriate timing and safety.

Is Zilretta safe for people with diabetes?

Corticosteroids like Zilretta can increase blood sugar levels. People with diabetes should have their blood glucose monitored closely after the injection.

How often can I receive Zilretta injections?

Repeat injections should not be given more frequently than every 3 months. Your doctor will assess your response and decide on further treatment.

Are there alternatives to Zilretta for knee osteoarthritis?

Yes, alternatives include immediate-release corticosteroid injections, hyaluronic acid injections, oral pain medications, physical therapy, and in some cases, surgery.

Can Zilretta be used in children or adolescents?

Zilretta is not recommended for use in pediatric patients, as safety and efficacy have not been established in this population.

What should I do if I experience severe pain or swelling after the injection?

Contact your healthcare provider immediately, as this may indicate infection or another serious complication.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.