Ziv-aflibercept (Zaltrap) (ziv-aflibercept) — Uses, Dosage, Side Effects & Safety

Drug class: Antineoplastic agent; Vascular Endothelial Growth Factor (VEGF) inhibitor

Overview

Ziv-aflibercept (Zaltrap) is a prescription cancer medication used in combination with other chemotherapy drugs to treat metastatic colorectal cancer (cancer of the colon or rectum that has spread to other parts of the body) in adults who have already received an oxaliplatin-containing regimen. It works by blocking vascular endothelial growth factor (VEGF), a protein that helps tumors form new blood vessels. By inhibiting VEGF, ziv-aflibercept reduces the blood supply to tumors, slowing their growth and spread. Key points for patients: Ziv-aflibercept is given as an intravenous infusion by a healthcare professional, usually every two weeks. It is important to attend all scheduled appointments and report any unusual symptoms to your doctor, especially signs of infection, bleeding, or severe abdominal pain.

Therapeutic uses

• Metastatic colorectal cancer
• Macular degeneration
• Diabetic macular edema
• Retinal vein occlusion

Common side effects

• Hypertension
• Proteinuria
• Hemorrhage
• Thromboembolic events
• Gastrointestinal perforation
• Fatigue
• Diarrhea

Frequently Asked Questions about Ziv-aflibercept (Zaltrap)

What is ziv-aflibercept (Zaltrap) used for?

It is used in combination with other chemotherapy drugs to treat metastatic colorectal cancer in adults who have previously received an oxaliplatin-based regimen.

How is ziv-aflibercept administered?

It is given as an intravenous infusion by a healthcare professional, usually every two weeks.

What are the most common side effects?

Common side effects include fatigue, diarrhea, decreased appetite, weight loss, mouth sores, and high blood pressure.

Can I take ziv-aflibercept if I am pregnant or breastfeeding?

No, ziv-aflibercept is not recommended during pregnancy or breastfeeding due to potential harm to the baby.

What should I do if I miss a dose?

Contact your healthcare provider as soon as possible to reschedule your infusion. Do not try to self-administer the medication.

Are there any foods or activities I should avoid?

Avoid activities that increase your risk of bleeding or injury, and do not receive live vaccines during treatment.

How does ziv-aflibercept work?

It blocks VEGF, a protein that helps tumors form new blood vessels, thereby reducing blood supply to tumors and slowing their growth.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.