Golimumab (golimumab) — Uses, Dosage, Side Effects & Safety

Drug class: Tumor Necrosis Factor (TNF) Inhibitor; Biologic Disease-Modifying Antirheumatic Drug (bDMARD)

Overview

Golimumab is a prescription medicine used to treat several autoimmune conditions, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. It works by blocking a substance in the body called tumor necrosis factor-alpha (TNF-α), which plays a key role in causing inflammation in these diseases. By reducing inflammation, golimumab helps relieve symptoms such as joint pain, swelling, and stiffness, and can prevent further joint damage. It is usually given as an injection under the skin or through an intravenous infusion, typically once a month. Patients should be aware that golimumab can weaken the immune system, making it easier to get infections. Regular monitoring and communication with your healthcare provider are important while using this medication.

Therapeutic uses

• Rheumatoid Arthritis (RA)
• Psoriatic Arthritis (PsA)
• Ankylosing Spondylitis (AS)
• Ulcerative Colitis (UC)

Common side effects

• Infections (serious)
• Injection site reactions
• Headache
• Elevated liver enzymes
• Increased risk of cancer
• Heart failure (new or worsening)
• Lupus-like syndrome
• Demyelinating disease

Frequently Asked Questions about Golimumab

What conditions does golimumab treat?

Golimumab is used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis by reducing inflammation in the body.

How is golimumab administered?

It is given as a subcutaneous injection once a month or as an intravenous infusion every 8 weeks, depending on your condition and your doctor's instructions.

What are the most common side effects?

Common side effects include upper respiratory infections, injection site reactions, headache, and fatigue.

Can golimumab increase my risk of infections?

Yes, golimumab can weaken your immune system, making you more susceptible to infections, including serious ones like tuberculosis.

Are there any medications I should avoid while taking golimumab?

Avoid using other biologic immunosuppressants or live vaccines while on golimumab. Always inform your doctor about all medications you are taking.

What should I do if I develop a fever or signs of infection?

Contact your healthcare provider immediately if you develop a fever, persistent cough, or other signs of infection while taking golimumab.

Is golimumab safe during pregnancy or breastfeeding?

The safety of golimumab during pregnancy and breastfeeding is not fully established. Discuss risks and benefits with your doctor if you are pregnant or planning to become pregnant.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.