Infliximab (infliximab) — Uses, Dosage, Side Effects & Safety

Drug class: Tumor Necrosis Factor (TNF) Inhibitor; Biologic Disease-Modifying Antirheumatic Drug (bDMARD)

Overview

Infliximab is a prescription medication used to treat several autoimmune and inflammatory conditions, including rheumatoid arthritis, Crohn’s disease, ulcerative colitis, ankylosing spondylitis, psoriatic arthritis, and plaque psoriasis. It works by blocking a protein in the body called tumor necrosis factor-alpha (TNF-α), which plays a key role in causing inflammation and tissue damage in these diseases. By reducing inflammation, infliximab helps relieve symptoms such as joint pain, swelling, diarrhea, and skin lesions. It is given as an intravenous (IV) infusion in a healthcare setting. Patients should be aware that infliximab can lower the immune system’s ability to fight infections, so regular monitoring and communication with your healthcare provider are important during treatment.

Therapeutic uses

• Crohn's Disease
• Ulcerative Colitis
• Rheumatoid Arthritis
• Psoriatic Arthritis
• Ankylosing Spondylitis

Common side effects

• Infusion reactions
• Upper respiratory tract infections
• Headache
• Nausea
• Abdominal pain
• Serious infections (e.g., tuberculosis, sepsis)
• Heart failure (new or worsening)
• Liver problems

Frequently Asked Questions about Infliximab

What conditions does infliximab treat?

Infliximab is used to treat autoimmune diseases such as rheumatoid arthritis, Crohn’s disease, ulcerative colitis, ankylosing spondylitis, psoriatic arthritis, and plaque psoriasis.

How is infliximab administered?

It is given as an intravenous infusion in a healthcare setting, usually over 2 hours. You will be monitored during and after the infusion for any reactions.

What are the most common side effects?

Common side effects include headache, respiratory infections, stomach pain, rash, and mild infusion reactions like fever or chills.

Can I receive vaccines while on infliximab?

You should avoid live vaccines while receiving infliximab. Inactivated vaccines may be given, but always consult your healthcare provider first.

What should I do if I miss a dose?

Contact your healthcare provider to reschedule your infusion. Do not try to self-administer or double up on doses.

Is infliximab safe during pregnancy or breastfeeding?

Infliximab should be used during pregnancy or breastfeeding only if clearly needed and after discussing risks and benefits with your doctor.

How long does it take for infliximab to work?

Some patients may notice improvement within a few weeks, but it can take several infusions (up to 12 weeks) to see the full benefit.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.