Urokinase (urokinase) — Uses, Dosage, Side Effects & Safety

Drug class: Cardiovascular & Circulatory System

Overview

Urokinase is a medication used to dissolve blood clots in the body. It is most commonly used to treat or prevent blockages in catheters and to manage serious blood clots in the lungs (pulmonary embolism) or other blood vessels. Urokinase works by activating the body's natural system for breaking down clots, helping to restore normal blood flow. This medicine is given by injection, usually in a hospital setting, under close medical supervision. Patients should know that urokinase can increase the risk of bleeding, so it is important to follow all instructions and report any unusual symptoms to your healthcare provider.

Therapeutic uses

• Pulmonary embolism
• Deep vein thrombosis
• Occluded intravenous catheters
• Myocardial infarction (off-label)

Common side effects

• Bleeding
• Allergic reactions
• Fever
• Nausea
• Vomiting
• Hypotension
• Chest pain

Frequently Asked Questions about Urokinase

What is urokinase used for?

Urokinase is used to dissolve blood clots in the lungs (pulmonary embolism), to clear blocked catheters, and in some cases to treat other serious blood clots.

How is urokinase administered?

It is given by intravenous infusion or directly into a catheter by a healthcare professional in a hospital setting.

What are the most common side effects?

The most common side effects are mild bleeding or bruising at the injection site, mild fever, or nausea.

Who should not receive urokinase?

People with active internal bleeding, recent major surgery or trauma, a history of hemorrhagic stroke, or severe uncontrolled high blood pressure should not receive urokinase.

Can urokinase be used in children?

Yes, but dosing is individualized and should only be administered by specialists experienced in pediatric care.

What should I do if I experience severe bleeding?

Seek emergency medical attention immediately. Severe bleeding is a medical emergency.

Are there any foods or activities I should avoid?

Avoid activities that may cause injury or bleeding, and avoid taking other blood thinners or NSAIDs unless directed by your doctor.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.