Xalkori (crizotinib) — Uses, Dosage, Side Effects & Safety

Drug class: Tyrosine kinase inhibitor (TKI); Antineoplastic agent

Overview

Xalkori is a prescription medicine used to treat certain types of non-small cell lung cancer (NSCLC) that are positive for either anaplastic lymphoma kinase (ALK) or ROS1 gene rearrangements. It is also used in some cases of relapsed or refractory systemic anaplastic large cell lymphoma (ALCL) in pediatric patients. Xalkori works by blocking specific proteins (ALK and ROS1 tyrosine kinases) that help cancer cells grow and spread. By inhibiting these proteins, Xalkori can slow or stop the growth of cancer cells. Key points for patients: Xalkori is taken by mouth as a capsule, usually twice daily. It is important to take it exactly as prescribed and to attend all scheduled medical appointments for monitoring. Common side effects include vision changes, nausea, diarrhea, and swelling. Serious side effects can occur, so report any unusual symptoms to your healthcare provider right away.

Therapeutic uses

  • Non-small cell lung cancer (NSCLC) that is anaplastic lymphoma kinase (ALK)-positive
  • Non-small cell lung cancer (NSCLC) that is ROS1-positive
  • Anaplastic large cell lymphoma (ALCL) that is ALK-positive
  • Inflammatory myofibroblastic tumor (IMT) that is ALK-positive

Common side effects

  • Vision disorders
  • Nausea
  • Diarrhea
  • Edema
  • Hepatotoxicity
  • Pneumonitis
  • Bradycardia
  • QT interval prolongation

Frequently Asked Questions about Xalkori

What is Xalkori used for?

Xalkori is used to treat certain types of non-small cell lung cancer (NSCLC) that are ALK-positive or ROS1-positive, and in some cases, relapsed or refractory systemic anaplastic large cell lymphoma (ALCL) in children.

How does Xalkori work?

Xalkori blocks the activity of specific proteins (ALK and ROS1 tyrosine kinases) that help cancer cells grow, thereby slowing or stopping cancer progression.

What are the most common side effects of Xalkori?

Common side effects include vision changes, nausea, vomiting, diarrhea, constipation, swelling, fatigue, and changes in taste.

Can I take Xalkori with other medications?

Xalkori can interact with many medications, especially those affecting liver enzymes or heart rhythm. Always check with your doctor or pharmacist before starting new medicines.

Is Xalkori safe during pregnancy or breastfeeding?

Xalkori can harm an unborn baby and should not be used during pregnancy. Breastfeeding is not recommended while taking Xalkori.

What should I do if I miss a dose?

Take the missed dose as soon as you remember, unless it is less than 6 hours before your next dose. Do not double up doses.

How long will I need to take Xalkori?

Treatment duration depends on your response and tolerance to the medication. Your doctor will determine how long you should continue therapy.

Related Xalkori information

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.