Mitotane (mitotane) — Uses, Dosage, Side Effects & Safety

Drug class: Cancer & Oncology

Overview

Mitotane is a prescription medication used to treat cancer of the adrenal glands, specifically adrenocortical carcinoma. It works by slowing the growth of cancer cells and reducing the production of certain hormones made by the adrenal gland. Mitotane is typically used when surgery is not possible or if the cancer has spread. It is taken by mouth as a tablet, usually under the supervision of a specialist. Patients should be aware that mitotane can cause significant side effects and requires regular monitoring by healthcare professionals. Key points: Mitotane may affect hormone levels, so you may need to take additional steroid medications. It is important to follow your doctor’s instructions closely and attend all scheduled blood tests to monitor your response and adjust your dose as needed.

Therapeutic uses

• Adrenocortical carcinoma
• Cushing's syndrome (off-label)
• Adrenal hyperplasia (off-label)

Common side effects

• Nausea
• Vomiting
• Diarrhea
• Dizziness
• Lethargy
• Adrenal insufficiency
• Rash

Frequently Asked Questions about Mitotane

What is mitotane used for?

Mitotane is used to treat cancer of the adrenal cortex (adrenocortical carcinoma), especially when the tumor cannot be removed surgically or has spread.

How does mitotane work?

Mitotane works by destroying adrenal cortex cells and reducing the production of adrenal hormones, helping to control tumor growth and hormone-related symptoms.

What should I do if I experience severe side effects?

Contact your doctor immediately if you experience severe confusion, vomiting, diarrhea, weakness, or signs of adrenal insufficiency. Seek emergency care for loss of consciousness or seizures.

Can I take mitotane during pregnancy?

Mitotane should not be used during pregnancy unless absolutely necessary, as it may harm the unborn baby. Use effective contraception while taking this medication.

Do I need regular blood tests while on mitotane?

Yes, regular blood tests are needed to monitor hormone levels, liver function, and drug levels to ensure safe and effective treatment.

Can mitotane interact with other medications?

Yes, mitotane can interact with many medications, including blood thinners, anti-seizure drugs, and hormonal therapies. Always inform your healthcare provider about all medicines you take.

How long will I need to take mitotane?

The duration of treatment depends on your response, side effects, and your doctor's recommendations. Some patients may need long-term therapy.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.