Niraparib (niraparib) — Uses, Dosage, Side Effects & Safety

Drug class: Cancer & Oncology

Overview

Niraparib is a prescription medicine used to treat certain types of ovarian, fallopian tube, or primary peritoneal cancer. It is most commonly used as maintenance therapy after initial treatment with chemotherapy, or for patients whose cancer has returned. Niraparib works by blocking an enzyme called PARP, which helps repair damaged DNA in cancer cells. By inhibiting this enzyme, niraparib makes it harder for cancer cells to repair themselves, leading to their death. Key points for patients: Niraparib is taken by mouth, usually once daily. It may help extend the time before cancer comes back or gets worse. Regular blood tests are needed to monitor for side effects, especially changes in blood counts. Always take niraparib exactly as prescribed and report any unusual symptoms to your healthcare provider.

Therapeutic uses

• Maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum-based chemotherapy.
• Treatment of adult patients with advanced ovarian, fallopian tube, or primary peritoneal cancer who have been treated with three or more prior chemotherapy regimens and who are platinum-sensitive.
• First-line maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum-based chemotherapy.

Common side effects

• Nausea
• Fatigue
• Thrombocytopenia
• Anemia
• Neutropenia
• Abdominal pain
• Vomiting
• Myelodysplastic syndrome/Acute myeloid leukemia

Frequently Asked Questions about Niraparib

What is niraparib used for?

Niraparib is used as maintenance therapy for adults with certain types of ovarian, fallopian tube, or primary peritoneal cancer, especially after successful initial chemotherapy or for recurrent disease.

How does niraparib work?

Niraparib blocks the PARP enzyme, which helps repair damaged DNA in cancer cells. By inhibiting this enzyme, niraparib prevents cancer cells from repairing themselves, leading to cell death.

What are the most common side effects of niraparib?

Common side effects include nausea, fatigue, constipation, vomiting, decreased appetite, and headache. Blood count changes are also frequent.

Can I take niraparib if I am pregnant or breastfeeding?

No. Niraparib can cause harm to an unborn baby and should not be used during pregnancy or breastfeeding. Use effective contraception during treatment and for at least 6 months after the last dose.

What should I do if I miss a dose?

Take the missed dose as soon as you remember on the same day. If it is almost time for your next dose, skip the missed dose. Do not double up doses.

How often will I need blood tests while taking niraparib?

You will need regular blood tests, especially during the first few months of treatment, to monitor for changes in blood counts and other side effects.

Are there any foods or medicines I should avoid while taking niraparib?

There are no specific food restrictions, but avoid medicines that may lower your blood counts or increase bleeding risk unless approved by your doctor.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.