Xeljanz (tofacitinib) — Uses, Dosage, Side Effects & Safety

Drug class: Autoimmune & Immunological

Overview

Xeljanz (tofacitinib) is a prescription medicine used to treat autoimmune conditions such as rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, and polyarticular juvenile idiopathic arthritis. It works by reducing inflammation in the body, which helps relieve symptoms like joint pain, swelling, and stiffness. Xeljanz belongs to a group of medicines called Janus kinase (JAK) inhibitors. It blocks specific enzymes involved in the immune system's inflammatory response. By doing so, Xeljanz helps control overactive immune reactions that cause damage in autoimmune diseases. Patients should know that Xeljanz can lower the body's ability to fight infections. Regular blood tests and monitoring are important while on this medication. It is important to take Xeljanz exactly as prescribed and to report any unusual symptoms to your healthcare provider.

Therapeutic uses

• Rheumatoid Arthritis
• Psoriatic Arthritis
• Ulcerative Colitis
• Ankylosing Spondylitis
• Polyarticular Course Juvenile Idiopathic Arthritis

Common side effects

• Upper respiratory tract infections
• Headache
• Diarrhea
• Nausea
• Serious infections (e.g., pneumonia, tuberculosis)
• Lymphoma and other malignancies
• Blood clots (e.g., DVT, PE)
• Gastrointestinal perforation

Frequently Asked Questions about Xeljanz

What conditions does Xeljanz treat?

Xeljanz is used to treat rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, and polyarticular juvenile idiopathic arthritis.

How long does it take for Xeljanz to work?

Some patients notice improvement in symptoms within a few weeks, but full effects may take up to 3 months.

Can I take Xeljanz if I have a history of infections?

Discuss your history with your doctor. Xeljanz can increase the risk of infections, so extra monitoring may be needed.

Is Xeljanz safe during pregnancy or breastfeeding?

Xeljanz is not recommended during pregnancy or breastfeeding unless clearly needed. Discuss risks and benefits with your doctor.

Do I need regular blood tests while taking Xeljanz?

Yes, regular blood tests are required to monitor blood counts, liver function, and cholesterol levels.

Can I receive vaccines while on Xeljanz?

You should not receive live vaccines while taking Xeljanz. Inactivated vaccines are generally safe but discuss with your doctor.

What should I do if I develop signs of infection while taking Xeljanz?

Contact your healthcare provider immediately if you develop fever, chills, cough, or other signs of infection.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.