Teriparatide (teriparatide) — Uses, Dosage, Side Effects & Safety

Drug class: Endocrine & Hormonal

Overview

Teriparatide is a prescription medication used to treat osteoporosis in adults who are at high risk for bone fractures, including postmenopausal women, men with primary or hypogonadal osteoporosis, and people with osteoporosis due to long-term glucocorticoid therapy. It is a synthetic form of parathyroid hormone (PTH 1-34) that helps stimulate new bone formation, making bones stronger and less likely to break. Teriparatide is typically used when other osteoporosis treatments have not worked or are not suitable. It is given as a daily injection under the skin, usually in the thigh or abdomen. Patients should be aware that teriparatide is generally limited to a maximum of 24 months of use in a lifetime due to potential risks. Key points: Teriparatide can help reduce the risk of fractures, but it may cause side effects such as dizziness or leg cramps. Patients should follow their healthcare provider's instructions closely and report any unusual symptoms immediately.

Therapeutic uses

• Treatment of osteoporosis in postmenopausal women at high risk for fracture
• Treatment of osteoporosis in men at high risk for fracture
• Treatment of glucocorticoid-induced osteoporosis in men and women at high risk for fracture
• Treatment of osteoporosis in men and women with hypogonadal osteoporosis at high risk for fracture

Common side effects

• Nausea
• Dizziness
• Leg cramps
• Joint pain
• Injection site reactions
• Osteosarcoma (rare, serious)
• Hypercalcemia

Frequently Asked Questions about Teriparatide

How does teriparatide help treat osteoporosis?

Teriparatide stimulates new bone formation by mimicking the action of parathyroid hormone, which increases bone mineral density and reduces the risk of fractures in people with osteoporosis.

How long can I use teriparatide?

Teriparatide is generally limited to a maximum of 24 months of use in a person's lifetime due to potential risks, including a possible increased risk of bone cancer.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember on the same day. Do not take two doses on the same day. Resume your regular dosing schedule the next day.

Can teriparatide be used in pregnancy or breastfeeding?

Teriparatide is not recommended during pregnancy or breastfeeding, as its safety in these populations has not been established.

What are the most serious risks of teriparatide?

The most serious risks include osteosarcoma (a rare bone cancer), hypercalcemia, and allergic reactions. It should not be used in people with certain bone diseases or a history of skeletal radiation.

How should teriparatide be stored?

Store teriparatide pens in the refrigerator at 36°F to 46°F (2°C to 8°C). Do not freeze. Discard the pen 28 days after first use.

Can I take calcium or vitamin D supplements with teriparatide?

You may need calcium and vitamin D supplements, but only take them as directed by your healthcare provider to avoid high calcium levels.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.